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Call for 8 Early Stage Researcher PhD fellowships in EDUCational Program on Factor VIII Immunogenicity.
 
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Original Call page on Euraxess | deadline: 08.05.2020

Introduction

EDUC8 is an Innovative Training Network (ITN) funded by the European Union Horizon 2020 Programme. The EDUC8 training network represents a novel, pioneering platform for studying the immunogenicity of therapeutic pro-coagulant factor VIII (FVIII) in patients with haemophilia A (HA). It includes leading scientists from academia and industry. The EDUC8 training network offers a total of 8 doctoral research projects (PhD projects) for 8 early stage researchers (ESRs) across 8 institutes in Europe. The research topics range from fundamental to translational science, and aim at identifying drug- and patient-related risk factors for the development of neutralizing anti-FVIII antibodies, and at developing innovative protocols for inducing tolerance to FVIII. Successful applicants will receive training in basic immunology, haemostasis research and bioinformatic approaches, clinical haemostasis, project management, entrepreneurship, healthcare economics, ethics and marketing. The interaction between biologists, clinical experts, healthcare professionals, industry and patients’ organizations is central to EUDC8. It will expose ESR to complex issues in bench-to-bedside research from different perspectives. Graduates from EDUC8 will be highly skilled, entrepreneurial and broadly-trained experts, equipped with innovative and beyond state-of-the-art proficiency on the exponentially expanding area of “immunogenicity of biotherapeutics”.

Research projects

The research activities implemented in EDUC8 have the following objectives:

  • To understand the immunogenicity of FVIII from drug and patients’ perspective.

  • To develop innovative methods to predict patients at risk of developing ADA in response to treatment.

  • To develop pioneering therapeutic approaches to prevent the development of FVIII inhibitors in patients with HA or to eradicate ongoing neutralizing immune responses.

The 8 Early Stage Researchers (ESR)’ projects are in the following table.

pdf Download all the information about the call and details of the individual ESR Projects

ESR TITLE OF THE PROJECT HOST INSTITUTION SHORT NAME SUPERVISOR START DATE
1 Induction of neonatal Fc receptor-mediated tolerance to therapeutic factor VIII in HA National Institute of Health and Medical Research
(Paris, France)
INSERM Sebastien Lacroix-Desmazes October 1st, 2020
2 Delineation of HLA-DP4-restricted FVIII peptidome Stichting Sanquin Bloedvoorziening-Sanquin
(Amsterdam, The Netherlands)
Sanquin Jan Voorberg October 1st, 2020
3 High-throughput B-cell epitopes profiling University of Milan
(Milan, Italy)
UMIL Flora Peyvandi
Roberta Palla
October 1st, 2020
4 Tolerance induction towards FVIII using CAR-transduced Tregs Goethe University
(Frankfurt, Germany)
GUF Christoph Königs
Stephan Schultze-Strasser
October 1st, 2020
5 Intracellular fate of endogenous FVIII variants and association with MHC University Clinic Bonn
(Bonn, Germany)
UKB Johannes Oldenburg
Heike Singer
October 1st, 2020
6 Induction of tolerance to therapeutic factor VIII in HA by modification with α2,3 sialic acid DC4U BV
(Amsterdam, The Netherlands)
DC4U Yvette van Kooyk
Ineke Rijnhout
October 1st, 2020
7 Induction of tolerance to therapeutic FVIII by harnessing the tolerogenic potency of the liver Topas Therapeutics GmbH
(Hamburg, Germany)
Topas Sabine Fleischer October 1st, 2020
8 Monitoring FVIII-specific T cell responses in healthy individuals and in HA patients Commissariat à l’énergie atomique et énergies alternatives
(Gif sur Yvette, France)
CEA Bernard Maillère October 1st, 2020

Training Programme

All the selected students will be involved in a highly stimulating training programme, both at the local and at
the network-wide level.

The training programme comprises:


  1. The implementation of the individual research project at the host institution. The research project will involve collaborations with other EDUC8 institutions, to be implemented through secondments.
  2. Each researcher will be involved in local training sessions.
  3. Joint scientific courses and meetings will be organised by the EDUC8 consortium, together with short courses for transferable skills training.
  4. Enrolment in PhD programmes of the following universities:
ESR HOST INSTITUTION UNIVERSITY RELEASING THE PhD
1 INSERM Sorbonne Université (Paris, France)
2 Sanquin AMC/University of Amsterdam (Amsterdam, The Netherlands)
3 UMIL University of Milan (Milan, Italy)
4 GUF Goethe University (Frankfurt, Germany)
5 UKB University Clinic Bonn (Bonn, Germany)
6 DC4U VU University (Amsterdam, The Netherlands)
7 Topas Goethe University (Frankfurt, Germany)
8 CEA Université Paris-Saclay (Gif sur Yvette, France)

Recruitment

The ESRs will be contractually employed for 36 months by the recruiting organisation and will be covered under the related national social security scheme. ESRs will receive a Monthly Living Allowance plus a Mobility Allowance (where applicable) compliant with the applicable EC Marie Skłodowska - Curie Actions - ITN
(https://ec.europa.eu/research/participants/data/ref/h2020/wp/2018-2020/main/h2020-wp1820-msca_en.pdf page 89 and 92)

Eligibility Rules

At the time of recruitment applicants must fulfil the following rules:

Eligibility Rules

  • Applicants must be in possession of the degree (usually the Master Degree) which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send a declaration of the university stating that the degree will be obtained before the expected starting date.

  • Applicants must be in the first 4 years of their research careers (full-time equivalent research experience) at the signature of the contract (measured from the time the Master’s degree has been obtained).

  • Eligible applicants must not hold a Doctoral degree already.

Eligibility Rules

The applicants must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date, and must not have carried out their main activity (work, studies, etc.) in that country.

Exceptions International Organisations: Eligible researchers must not have spent more than 12 months in the 3 years immediately prior to the date of selection in the same appointing international organisation.

How to apply

EDUC8 will select ESR through a 2-step recruitment process.

EDUC8 will select ESR through a 2-step recruitment process. Candidates should submit their application for their top two preferred research projects. Applications (in English) should include:

  1. an updated CV; the CV must be without gaps, in order to easily check the mobility and experience requirements. CVs that either do not clearly show the applicant’s past experience, or have gaps, will be considered ineligible.
  2. a letter giving reason for his/her motivation for the position;
  3. at least 1 reference letter (in English) from one former supervisor and/or lecturer;
  4. the scan of the degree (usually the Master Degree) which would formally entitle him/her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send a declaration of the university stating that the degree will be obtained before the expected starting date;
  5. transcripts of records (document indicating their ranking and marks within their last year at their Master Degree as well as the courses/modules they have followed).

Applications must be in English and will be evaluated against the following criteria:
- educational record;
- scientific quality of the applicant’s CV;
- expected individual impact and benefit to the fellow and to the project.
- previous experience in the subject of EDUC8 research programme.

The closing date for applications is 8th May, 2020.

Application documents should be sent by email to the relevant project supervisors by email (see individual project descriptions).


The candidates will be evaluated on the basis of the received documents and the best 8 candidates for each position will be invited for a Skype interview that will take place in the period between the 11th- 22nd May 2020. For each position a short list will be prepared and notified to the applicants.
The 2 top candidates for each position will be invited for a virtual interview (on the 3rd or 4th June 2020). The final selection of the ERSs will be made at the end of interview rounds and candidates will be informed immediately.


pdf Download all the information about the call and details of the individual ESR Projects top
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This project has received funding from the European Union’s
Horizon 2020 research and innovation programme under the
Marie Skłodowska-Curie grant agreement No 859974

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Last update: April 01, 2020


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