June 27, 2021
Hemophilia A and therapies
Eleonora Nardini, Vumc
Payal Suresh Chawla, University Clinic Bonn
Valeria Porcheddu, Commissariat à l’énergie atomique et énergies alternatives
Among all the bleeding disorders, hemophilia is widely known. It is also referred to as “the royal disease”, since the monarchs of the UK, Germany, Spain and Russia were affected in the 19th and 20th centuries.
May 27, 2021
Blood coagulation FVIII: an overview
Mariarosaria Miranda, Stichting Sanquin Bloedvoorziening
Eleonora Nardini, Vumc
Puneet Tomar, University of Milan
Sarah Scatigna, Goethe University
Factor VIII plays a key role in the intrinsic pathway of the blood coagulation cascade. In its active form, FVIIIa acts as a cofactor for the proteolytic activation of FX by the serine protease FIXa.
April 30, 2021
Bleeding Disorders
Payal Chawla, Universitätsklinikum Bonn
Alejandra Reyes Ruiz, National Institute of Health and Medical Research
Valeria Porcheddu, Commissariat à l’énergie atomique et énergies alternatives
Under normal physiological conditions, a balance between clotting and bleeding is always maintained.
February 18, 2021
FVIII: a crucial hemostatic factor to control bleeding
Puneet Tomar, University of Milan
Mariarosaria Miranda, Stichting Sanquin Bloedvoorziening
When blood loss - either outside of the body or blood vessels - takes place, a process to prevent and stop bleeding occurs, this is called hemostasis.